集成IDPC集群分析和可解释机器学习,用于预测ESCC患者的生存风险
Dan Ling1, Anhao Liu1, Junwei Sun1
1Henan Key Lab of Information-Based Electrical Appliances, Zhengzhou University of Light Industry, Zhengzhou, 450002, China.
概括
本研究引入了一种可解释的食道状细胞癌 (ESCC) 的生存风险预测模型,使用WOA-XGBoost和SHAP. 这种新的方法提高了预测准确性和可解释性,从而改善了患者的预后.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 机器学习 机器学习
背景情况:
- 准确的生存风险预测对于食道状细胞癌 (ESCC) 患者的预后至关重要.
- 目前ESCC的预测方法往往缺乏足够的适配能力和可解释性.
- 需要先进的,可解释的模型来提高对ESCC患者结果的理解.
研究的目的:
- 为ESCC患者开发一种新的,可解释的生存风险预测方法.
- 提高现有的黑子预测模型的准确性和可解释性.
- 确定影响ESCC生存风险的关键因素.
主要方法:
- 利用自适应合成采样 (ADASYN) 来解决数据不平衡并生成高风险样本.
- 采用了通过快速搜索和发现密度峰值 (IDPC) 算法来进行患者分层的改进的集群.
- 使用鱼优化算法改进的极端梯度提升 (WOA-XGBoost) 开发了一个可解释的预测模型,并使用沙普利增量解释 (SHAP) 进行可视化.
主要成果:
- 拟议的WOA-XGBoost和SHAP模型在预测ESCC的生存风险方面表现出卓越的表现.
- 在接收器操作特征曲线 (AUROC) 下达到0.918.8的高面积.
- 达到0.881的准确性,表明有效的预测能力.
结论:
- 开发的可解释的生存风险预测方法比ESCC的现有方法提供了显著的改进.
- WOA-XGBoost和SHAP的组合提高了模型的解释性,有助于确定预后因素.
- 这种方法为临床医生在管理ESCC患者和预测其预后方面提供了宝贵的工具.
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