持续输注万科米辛作为门诊直肠直肠抗菌药物治疗的患者安全结果
Russell J Benefield1,2, Joshua McDonald1, Michael Newman3
1Department of Pharmacy, University of Utah Health, Salt Lake City, Utah, USA.
连续输注万科米辛并没有减少门诊亲肠道抗菌药物治疗 (OPAT) 中的毒性或不良事件. 放出时度 - 时间曲线 (AUC) 下的万科米辛面积是提高OPAT中万科米辛安全性的关键.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 理论上,持续输注万科米辛可以减少毒性.
- 有限的数据存在于连续输注万科米辛在门诊亲肠道抗菌疗法 (OPAT) 程序.
结论:
- 持续输液万科米辛对门诊患者的安全结果没有明显的好处.
- 以AUC为中心的剂量策略需要进一步调查,以提高OPAT中万科米辛的安全性.
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