甲状腺功能和肥胖现象类型之间的关联在健康的甲状腺患者中:基于德黑兰甲状腺研究的调查
Behnaz Abiri1, Amirhossein Ramezani Ahmadi2, Maryam Mahdavi1
1Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-476, Tehran, Iran.
European journal of medical research
|May 29, 2023
概括
甲状腺功能,特别是自由甲状腺素 (FT4),与 euthyroid个体的肥胖表型有关. 较低的FT4水平与代谢不健康的肥胖有关,这表明在代谢健康中发挥了作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 甲状腺功能 甲状腺功能
背景情况:
- 甲状腺激素在调节新陈代谢方面发挥着至关重要的作用.
- 肥胖与各种代谢异常有关.
- 甲状腺功能和肥胖现象类型之间的关系需要进一步阐明.
研究的目的:
- 为了研究甲状腺功能和不同肥胖现象类型之间的关联,在 euthyroid 成年人.
- 为了确定甲状腺激素水平是否在代谢健康和不健康的正常体重和肥胖个体之间存在差异.
主要方法:
- 来自德黑兰甲状腺研究 (TTS) 的2988名甲状腺功能良好的成年人的横截面分析.
- 将参与者分为四种肥胖现象型:代谢健康的正常体重 (MHNW),代谢健康的肥胖者 (MHO),代谢不健康的正常体重 (MUNW) 和代谢不健康的肥胖者 (MUO).
- 甲状腺激素水平 (TSH,FT4) 在使用ANCOVA的表型之间进行比较,对混变量进行调整,并根据年龄和性别对子组进行分析.
主要成果:
- 与代谢不健康的肥胖个体相比,MHNW表型的甲状腺腺体个体表现出较高的自由甲状腺素 (FT4) 水平.
- 在整个肥胖表型中,甲状腺刺激激素 (TSH) 水平没有显著差异.
- 亚组分析显示,FT4差异仅在55岁以下的个体中显著.
结论:
- 超重/肥胖的乙甲状腺体患者的代谢异常与较低的正常FT4水平独立相关.
- 需要进一步的研究,以了解低FT4与甲状腺细胞群中代谢不健康状态之间的联系机制.
- 这些发现突出了甲状腺功能在肥胖的代谢后果中的潜在作用.
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