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在切除的非小细胞肺癌中,局部区域复发的分子风险因素

Wei Guo¹, Tao Zhang², Runze Li¹

¹Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cancer medicine

|May 30, 2023

概括

在手术后非小细胞肺癌 (NSCLC) 中,局部复发很常见. 基因组生物标志物如TP53和ctDNA中的EGFR突变可以预测这种复发风险.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
胸部外科手术胸部外科手术

背景情况:

局部区域性复发 (LR) 在非小细胞肺癌 (NSCLC) 中具有显著的风险和不良预后.
有效的局部控制对于在NSCLC患者中实现彻底治愈至关重要.
与临床病理因素相比,NSCLC中LR的基因组生物标志物仍未得到充分研究.

研究的目的:

在手术切除后调查与非小细胞肺癌 (NSCLC) 局部区域性复发相关的基因组生物标志物.
为了确定独立于远程转移风险的局部区域复发风险的预测标志物.

主要方法:

对118名接受NSCLC切除的患者的瘤和血液样本进行分析,以进行突变分析.
收集治疗前/术后血液样本进行循环瘤DNA (ctDNA) 分析.
基因组发现与局部区域复发 (LR) 和远程转移 (DM) 率的相关性.

主要成果:

几乎一半的复发是局部区域 (46%);三年LR风险为25%.
较高的基线ctDNA水平和等位基因频率异质性独立地与增加的LR风险有关.
破坏性TP53突变与较低的无LR存活率相关,而EGFR突变对LR具有有利的预后值.

结论:

来自瘤和ctDNA的基因组生物标志物在NSCLC中预测LR的预后价值.
无论远程转移风险如何,都可以识别患有LR高风险的患者.
TP53和EGFR突变是NSCLC中LR的显著预后因素.

关键词:

在NSCLCLC中,我们可以看到.辅助疗法是一种辅助疗法.生物标志物生物标志物遥远的复发遥远的复发地方区域的复发情况.

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