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类似病毒的二氧化纳米粒子增强了宏分子透in vivo

Yuxue Cao¹, Taskeen Iqbal Janjua¹, Zhi Qu¹

¹School of Pharmacy, The University of Queensland, Brisbane, QLD, 4102, Australia. a.popat@uq.edu.au.

Biomaterials science

|May 30, 2023

概括

类似病毒的小型纳米颗粒 (VSNP) 通过暂时打开肠道来增强口服生物传递. 阴性VSNP在细胞模型和小鼠中表现出优异的透增强,与球状纳米颗粒相比.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

纳米粒子透增强剂在口服生物交付方面表现有前途.
固体二氧化纳米颗粒可以暂时打开肠道上皮质,改善和蛋白质的吸收.

研究的目的:

开发小尺寸 (∼60 nm) 病毒类的纳米颗粒 (VSNP) 作为一种新的,无毒的透增强剂,用于口服生物输送.
评估VSNP在增强肠道通透性的有效性.

主要方法:

小尺寸 (∼60 nm) 病毒类的纳米颗粒 (VSNP) 的开发.
使用Caco-2细胞单层和共同培养模型评估VSNP透增强效应.
在健康小鼠体内评估VSNP,使用光标记的德克斯.

主要成果:

阴性VSNP在Caco-2细胞中提高了1.3倍的胰岛素透性,在共同培养模型中提高了1.2倍,优于球形Stöber二氧化纳米颗粒.
与Stöber纳米粒子和正电荷的VSNP相比,离子VSNP的口服剂在小鼠中显著增加了4kDa德克斯的透率.
纳米级表面粗度被确定为有效透增强的关键因素.

结论:

具有纳米级表面粗度的小尺寸 (∼60 nm) 病毒类纳米粒子 (VSNP) 是有效的无毒透增强剂.
阴性VSNP在治疗性和蛋白质的口服输送方面表现出卓越的性能.
VSNP代表了一种有希望的下一代战略,用于提高生物制剂的口服生物可用性.

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