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基于社区的尸体解剖队伍中的尿失禁与边缘主导与年龄相关的TDP-43脑病变神经病理变化有关

Jing Di¹, Ruth S Nelson², Gregory A Jicha^3,4

¹Department of Pathology and Laboratory Medicine.

Journal of Alzheimer's disease : JAD

|May 30, 2023

概括

老年人尿失禁与痴呆和抑郁症有关. 临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 在这个尸体解剖研究中与UI最强烈相关.

科学领域:

神经病理学神经病理学
老年医学老年医学
神经退行性疾病神经退行性疾病

背景情况:

痴呆症和尿失禁 (UI) 是复杂的疾病,通常在个人中同时发生.
连接痴呆症和UI的潜在因素仍然不完全理解.
调查共同的病理对于理解这些疾病至关重要.

研究的目的:

在社区的尸检系列中调查尿失禁 (UI) 的神经病理基础.
在老年人中识别与UI相关的特定大脑病理.

主要方法:

利用肯塔基大学阿尔茨海默氏病研究中心368名志愿者的尸检数据.
使用统计模型来评估神经病理发现和UI之间的关联.
综合常规阶段与定量数字神经病理学进行全面分析.

主要成果:

在42.7%的参与者中诊断出UI,并与痴呆和抑郁症有关.
临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 与UI有很强的关联 (p < 0.001).
晚期NC与UI相关,无论是阿尔茨海默氏症还是莱维体病理.

结论:

多种因素导致老年人UI.
临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 是UI的重要神经病理相关物.
对LATE-NC的进一步研究可能会揭示UI在老年人群中的治疗点.

关键词:

ADNC ADNC ADNC 的意思是什么意思.阿尔塔格 (ARTAG) 是一个古老的城市.扫描仪 (ScanScope) 是一个扫描仪.临床痴呆症评级临床痴呆症评级产科产科产科产科最古老的-最古老的-最古老的在性爱中,性爱是性爱.一个同核蛋白.泌尿病学泌尿病学泌尿病学

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