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CEP128基因对放射治疗相关脑损伤的调制效应:使用多参数脑MRI图像进行纵向结构研究

Shiwei Lin¹, Xiaofei Lv², Xiaoshan Lin¹

¹Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China.

Journal of magnetic resonance imaging : JMRI

|May 30, 2023

概括

CEP128基因变体rs17111237影响了鼻癌 (NPC) 患者的放射治疗诱导的大脑变化. 形态相似性网络 (MSN) 揭示了这些变化,突出 CEP1288.

科学领域:

神经成像是一种神经成像.
遗传学遗传学是一个
在瘤学瘤学.

背景情况:

鼻癌 (NPC) 的放射治疗 (RT) 可以导致脑损伤.
CEP128基因促进体变体rs17111237与NPC患者的RT相关的大脑亡有关.

研究的目的:

在NPC患者的RT后调查动态大脑形态变化.
探索这些变化背后的遗传机制,重点关注CEP128变体.
评估CEP128遗传变异如何调节RT相关的大脑变化.

主要方法:

一项对101名NPC患者和19名健康对照者的纵向研究.
3D脑部成像 (3D-BRAVO,扩散加权成像) 在3.0T.
桑格测序用于rs17111237,FreeSurfer/FSL用于图像处理,以及形态相似性网络 (MSN) 构建.

主要成果:

在RT后的NPC患者中观察到显著的广泛MSN变化.
区域MSN变化与CEP128基因表达有负相关性.
CEP128中的rs17111237变体显著调节了这些MSN变化,最显著的是RT后3个月.

结论:

MSN分析可以作为一个敏感的生物标志物来检测RT相关的大脑损伤.
在RT诱导的大脑损伤的可变性可能会受到CEP128基因表达和rs17111237促进体变异的影响.

关键词:

CEP1288,可以使用CEP128 形态相似性网络的形态相似性网络.鼻癌 (nasopharyngeal carcinoma) 是一种发生在鼻的癌症.辐射疗法辐射疗法

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