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用于UHDR FLASH放射治疗的二极管剂量计的表征

Mahbubur Rahman^1,2, Jakub Kozelka³, Jeff Hildreth³

¹Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.

Medical physics

|May 30, 2023

概括

EDGE检测器适用于超高剂量率 (UHDR) FLASH放射治疗剂量计,准确测量剂量,剂量率和每脉冲剂量. 它的稳定性和亚毫秒分辨率可以在治疗期间进行潜在的体内监测.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
剂量测量方法剂量测量方法

背景情况:

在FLASH放射治疗中,超高剂量速率 (UHDR) 束超过40 Gy/sec.
准确的表征需要具有高时间分辨率和快速读数的剂量计.
现有的剂量计在精确测量UHDR光束参数方面面临着挑战.

研究的目的:

描述一个二极管EDGE检测器与UHDR电子束剂量计的新电表.
评估其适用于UHDR FLASH放射治疗应用的适用性.
根据既有剂量测量方法评估其性能.

主要方法:

EDGE检测器的量化剂量线性,平均剂量速率和每脉冲剂量依赖性.
将EDGE检测器测量结果与W1闪电器,放射性色膜和电离室进行比较.
使用基于闪的反机制来控制剂量,并使用LINAC重复率来控制剂量.
在单个脉冲分辨率下分析了深度剂量概况和时间概况.

主要成果:

EDGE 探测器同意在剂量为 2%,剂量速率为 5%,每脉冲剂量为 1% 的范围内进行膜测量.
在每脉冲剂量的2%以内 (高达0.78 Gy/脉冲) 与W1闪电器达成一致.
对于剂量 (0.4%) 和平均剂量速率 (0.2%) 与电离室有很好的一致性.
辐射诱导的反应减少是最小的,为0.4%/kGy.

结论:

EDGE探测器表现出剂量线性和独立于UHDR电子束的平均剂量速率和每脉冲剂量.
它准确地量化了光束的空间和时间特征,分辨率低于毫秒.
它的性能表明在体内FLASH剂量测量和治疗期间实时剂量监测的潜力.

关键词:

边缘探测器 EDGE 探测器一个闪光灯.二极管二极管是如何使用的电影电影电影电影电影电离室的电离室超高剂量速率的超高剂量速率

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