多功能聚合物涂层具有自我吸附,抗和in situ再矿化特性,用于治疗
Wenlin Chu1, Haiqin Tang2, Zhiyun Dong2
1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China. helibang@163.com.
Journal of materials chemistry. B
|May 30, 2023
概括
一种新的共聚合物涂层,聚乙烯糖醇-聚酸-氨酸 (PEG-PAsp-ALN),有效抑制细菌粘附并促进牙重矿化. 这种生物活性涂层为预防和治疗牙提供了一个有希望的策略.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 聚合物化学 聚合物化学
背景情况:
- 牙损是一种由生物膜诱导的疾病,导致牙面膜去矿化.
- 早期的细菌和蛋白质粘附开始了牙上生物膜的形成.
- 寻求多功能材料,以有效治疗牙腐烂.
研究的目的:
- 合成和描述一种用于牙科应用的新型双功能涂层.
- 评估涂层在防止生物膜形成和促进重矿化方面的有效性.
- 评估牙表面涂层的安全性和结合能力.
主要方法:
- 合成双块共聚合物聚乙烯甘醇-聚酸 (PEG-PAsp) 的合成.
- 修改PEG-PAsp与阿伦德罗酸 (ALN),以产生PEG-PAsp-ALN涂层.
- 对蛋白质和细菌粘附抑制,牙表面结合和重矿化功效的评估.
主要成果:
- PEG-PAsp-ALN涂层成功地抑制了蛋白质和细菌的粘附.
- 涂层通过PAsp和ALN强烈的协同结合牙表面.
- 观察到显著的in situ重矿化,以及抑制生物膜形成.
- 这种治疗方法保持了出色的安全性.
结论:
- 开发的PEG-PAsp-ALN共聚合物涂层作为牙的生物活性,多功能层.
- 这种方法显示出有效预防和治疗牙的巨大潜力.
- 涂层有助于同时抑制生物膜和面膜重矿化.
更多相关视频
06:022-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
Published on: December 26, 2016
10.4K
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
6.4K
相关概念视频
Biofilms
61
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
61
Complexometric Titration: Ligands
1.0K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
1.0K
Waterproofing and Anti-Bacterial Admixtures in Concrete
104
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
104
