相关实验视频

Updated: Jul 28, 2025

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

在患有食道癌的患者中,对三级淋巴体结构和免疫微环境的综合分析

Yuanshan Yao¹, Haojie Xuan¹, Jing Wang¹

¹Department of Thoracic Surgery, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.

|May 30, 2023

概括

在食道状细胞癌 (ESCC) 中出现三级淋巴体结构 (TLS) 表示更好的预后和炎症瘤微环境. TLS基因特征 (TLS-9和TLS-12) 显示出作为预测ESCC患者免疫治疗反应的生物标志物的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

食道状细胞癌 (ESCC) 是一种普遍存在的上部胃肠道恶性瘤.
三级淋巴体结构 (TLS) 是瘤内的免疫和 stromal 细胞的聚合物,类似于二级淋巴体器官.
了解TLS的作用对于预测ESCC的预后和免疫疗法的有效性至关重要.

研究的目的:

研究与TLS模型相关的两个常见基因特征对ESCC患者的预后和免疫治疗结果的预测影响.
探索TLS签名与瘤微环境,临床指标,基因组负担和ESCC中的干性之间的关联.

主要方法:

收集了TCGA和GSE53625队列中ESCC患者的临床数据.
量化了TLS得分 (TLS_9用于免疫细胞组成,TLS_12用于新生体),并分析了它们与免疫细胞透,瘤微环境,基因组负担和干性相关性.
通过组织微阵列 (TMA) 评估成熟的TLS存在,用于预后评估.

主要成果:

TLS评分 (TLS_9和TLS_12) 与CD8+T细胞,NK细胞,CD4+T细胞和M1巨细胞的透正相关.
较高的TLS得分与增加的免疫功能障碍和减少的免疫排斥有关.
在ESCC组织中存在成熟的TLS与更好的患者预后相关.

结论:

患有TLS的ESCC患者表现出改善的结果和更炎症的免疫微环境.
在ESCC中,TLS-9和TLS-12基因签名作为预测免疫治疗反应的潜在生物标志物.
在食道状细胞癌中,TLS的存在是有利的预后指标.

关键词:

在 ESCC ESCC 的位置上.在 TLS 中使用 TLS.与TLS基因相关的签名免疫疗法免疫疗法预后预后预后

更多相关视频

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...