在2型糖尿病患者中,限度腹手术诱导的减肥:脂肪组织中的预测变量
Óscar Osorio-Conles1,2, Amanda Jiménez2,3,4, Ainitze Ibarzabal5
1Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
The Journal of clinical endocrinology and metabolism
|May 30, 2023
概括
2型糖尿病 (T2D) 与减肥手术 (BS) 后的体重减轻 (WL) 有关. 皮下脂肪组织 (AT) 中失调的宏自可能解释了这一点,影响了WL的结果.
科学领域:
- 代谢手术 代谢手术
- 内分泌学 在内分泌学.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 2型糖尿病 (T2D) 在减肥手术 (BS) 后对减肥 (WL) 的影响是有争议的,对潜在机制的理解有限.
- 脂肪组织 (AT) 的特征可能会影响BS后的WL成功,特别是在T2D患者中.
研究的目的:
- 调查BS后T2D和WL结局之间的关系.
- 在接受BS的T2D和无T2D患者中,确定AT参数和WL之间的新兴关联.
主要方法:
- 评估了1659名患有和没有T2D的患者 (队列1) 的中期WL轨迹.
- 分析了48对匹配对的皮下和内脏AT样本,以评估AT参数和基因表达.
- 探索了AT参数与WL响应之间的关联.
主要成果:
- 在队列1中,T2D独立地与5%较少的中期WL相关.
- 在AT中皮下ATG7表达被确定为术后一年有限WL的独立预测因子.
- 在皮下AT中失调的宏自被认为是T2D患者减少WL的潜在贡献者.
结论:
- 在BS之后,T2D是有限WL的重要决定因素.
- 皮下脂肪组织中的宏观自可能在经过BS的T2D患者观察到的减少WL中发挥作用.
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