拉坦诺普罗斯特的持久性和坚持性:丹麦基于登记册的对老年患有青光眼的老年患者的队列研究
Diva Amiri1, Maurizio Sessa2, Morten Andersen2
1Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Acta ophthalmologica
|May 30, 2023
概括
切换到无防腐剂的拉坦诺普罗斯特 (Monoprost®) 或拉坦诺普罗斯特眼药之间显著改善了老年丹麦绿眼病患者的药物坚持和持续性. 这表明配方选择影响治疗成功.
科学领域:
- 眼科医生 眼科 眼科
- 药物经济学 药物经济学
- 临床药房 临床药房
背景情况:
- 在控制眼内压力和预防视力丧失方面,坚持和坚持治疗青光眼症至关重要.
- 拉塔诺普罗斯特眼药滴是常见的青光眼的第一线治疗方法.
- 在配方之间切换或使用无防腐剂的选择可能会影响患者的坚持.
研究的目的:
- 评估65岁以上的丹麦患者中切换模式和坚持/坚持之间的关联,这些患者开始服用拉坦诺普罗斯特眼滴.
- 为了比较非切换者,切换者之间拉坦诺普罗斯特配方,以及无防腐剂拉坦诺普罗斯特 (Monoprost®) 的用户之间的坚持和停止风险.
主要方法:
- 一项回顾性队列研究,涉及65岁以上的丹麦患者,他们首次开始使用拉坦诺普罗斯特治疗青光眼.
- 患者被分为三个组:切换者,非切换者和没有防腐剂的拉坦诺普罗斯特 (Monoprost®) 用户.
- 倾向性得分匹配和考克斯回归分析被用来评估1年的治疗中止风险.
主要成果:
- 与非切换者 (92%) 相比,在切换者 (96%) 和Monoprost®用户 (99%) 中观察到更高的坚持 (覆盖日数比例).
- 与不切换者相比,切换者的治疗中止风险较低53% (HR 0.47;p<0.001).
- 莫诺普罗斯特使用者显示,与未切换者 (HR 0.22;p<0.001) 相比,切断药物的风险显著降低 (78%降低).
结论:
- 在老年玻璃眼患者中,切换拉坦诺普罗斯特配方和使用无防腐剂选择 (Monoprost®) 与改善粘附性和持久性有关.
- 这些发现凸显了考虑配方类型和切换模式的重要性,以加强长期的玻璃眼瘤管理.
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