一种可降解的持续释放药物输送系统用于形成斑块的玻璃眼手术
Ralph J S van Mechelen1,2, Jarno E J Wolters1,2, Sebastian Fredrich3
1University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), Maastricht, 6202 AZ, The Netherlands.
Macromolecular bioscience
|May 30, 2023
概括
使用米托米辛C (MMC) 的新药物输送系统显示出对玻璃眼外科手术的前景. 这些系统可以减少白血纤维化,这是手术失败的常见原因,可能为当前治疗提供一种不太有毒的替代方案.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 过血栓的纤维化是绿眼外科手术失败的主要原因.
- 目前的标准治疗包括手术内使用的米托辛C (MMC),它具有细胞毒性,通常需要多次应用.
- 需要更安全,更有效的方法来控制纤维化反应.
研究的目的:
- 为MMC开发和评估可生物降解,持续释放的药物输送系统 (DDS).
- 为了比较MMC加载的聚烯酸 (PCL) 和聚乳糖合糖酸 (PLGA) DDS与常规的MMC溶液的疗效和安全性,在子眼手术模型中.
- 评估这些DDS对血栓功能,炎症和组织反应的影响.
主要方法:
- 两种类型的生物降解DDS (PCL和PLGA) 装有MMC.
- 在试验室中评估了释放动力学.
- 子模型使用PCL-MMC DDS,PLGA-MMC DDS或传统的MMC解决方案接收了PRESERFLO MicroShunt.
- 在手术后的28日和90日评估了Bleb形态,功能,炎症和异物反应.
主要成果:
- PLGA DDS释放了99%的MMC,而PCL DDS释放了75%的MMC.
- 所有手术组在术后90天内都保持了功能性血栓.
- 与对照组相比,DDS组表现出更多的炎症和无血管血栓,但与对照组相比,原蛋白排列更松散.
- 在PLGA DDS中,炎症和外体反应较少,在第90天的降解更为完全.
结论:
- 持续释放的MMC DDSs是可行的绿眼的手术,潜在地减少白内障纤维化.
- 与PCL DDS相比,PLGA DDS在炎症和降解方面显示出有利的概况.
- 进一步优化剂量是必要的,以减轻结膜性副作用.
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