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第一个和第二个三个月的细胞自由DNA胎儿分数与自发早产之间的关联

Yanmei Luo¹, Liang Xu¹, Yongyi Ma¹

¹Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Expert review of molecular diagnostics

|May 30, 2023

概括

这项研究发现,怀孕期间的无细胞胎儿DNA分数与自发早产之间没有显著的联系. 分析了来自14000多个怀孕的非侵入性产前检测数据,证实了这种缺乏关联.

科学领域:

产前诊断在产前诊断
遗传学是一个遗传学.
产科产科产科产科产科

背景情况:

非侵入性产前检测 (NIPT) 分析母体血液中的无细胞胎儿DNA (cfDNA).
cfDNA的胎儿分数 (FF) 是NIPT的一个关键指标.
影响FF的因素包括母亲的特征和妊娠年龄.

研究的目的:

调查第一和第二个月的cfDNA胎儿分数与自发早产之间的关联.
为了确定在NIPT期间测量的FF是否可以预测自发早产风险.

主要方法:

对接受NIPT的单独怀孕的回顾性队列研究.
患者分为预产期 (≥37周) 和自发早产 (<37周) 出生组.
对混因子进行调整后勤回归分析,以评估FF和自发早产相关性.

主要成果:

分析了14,020例怀孕;5.19%经历了自发的早产.
胎儿分数与母亲年龄和BMI相反相关;与妊娠年龄,生育能力和ART相对正相关.
在对共变量进行调整后,没有发现cfDNA胎儿分数和自发早产之间具有统计意义的关联.

结论:

该研究得出结论,在NIPT期间测量的cfDNA胎儿分数与自发早产无关.
在单子妊娠中,FF水平似乎不是自发早产的预测标志物.

关键词:

没有细胞的胎儿DNA.胎儿分数胎儿分数非侵入性的产前检测.这是自发的早产.第一个和第二个三个月的孕期.

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