LINC00460有助于结直肠癌细胞入侵
Weiguo Ren1, Xuexiu Zhang1, Qiang Li2
1Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Biotechnology & genetic engineering reviews
|May 30, 2023
概括
长非编码RNA LINC00460促进结直肠癌 (CRC) 侵袭和转移. 升高的LINC00460表达与预后不佳有关,可以作为CRC患者的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 大肠直肠癌 (CRC) 是全球领先的恶性瘤.
- 长非编码RNAs (LncRNAs) 越来越多地与癌症的发展有关.
- 了解LncRNA的作用对于CRC瘤发生和进展研究至关重要.
研究的目的:
- 为了研究LINC00460在结直肠癌中的作用.
- 评估LINC00460作为CRC的潜在诊断和预后生物标志物.
主要方法:
- 在两个独立的CRC数据集 (GSE39582,GSE21510) 中对LINC00460进行选.
- 在98个CRC组织和细胞系中量化LINC00460表达.
- 在CRC细胞系中对LINC00460进行siRNA介导的淘汰.
- 分析LINC00460表达与临床病理特征和预后的相关性.
主要成果:
- 与正常对照组相比,LINC00460表达在CRC组织和细胞系中显著上调.
- LINC00460 敲除降低了CRC细胞的入侵,但没有扩散.
- 高LINC00460表达与淋巴结转移,远程转移和高级TNM阶段相关.
- 过度表达LINC00460与CRC患者的整体存活率较低有关.
- LINC00460表达和TNM阶段是CRC的独立预后因素.
结论:
- 在结直肠癌的入侵和转移中,LINC00460起着致癌作用.
- LINC00460可以作为CRC的宝贵诊断和预后生物标志物.
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