氧化NHC催化:一种非传统的工具,用于合成宏循环橄酸
Marco Bottin1, Graziano Di Carmine1, Olga Bortolini2
1Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via L. Borsari, 46, 44121, Ferrara, Italy.
一种新的N- heterocyclic carbene (NHC) 催化方法提供了一种原子经济的,无金属的途径,用于使用绿色溶剂和可回收氧化剂的宏环氧化氧化物 (MCO). 这种方法可以有效地获得来自不同单体的有价值的宏循环.
科学领域:
- 有机化学 有机化学
- 聚合物化学 聚合物化学
- 可持续化学 可持续化学
背景情况:
- 传统的宏环氧化 (MCOs) 合成往往涉及有毒的试剂,如二甲化.
- 开发更绿色,更原子经济的合成路线对于可持续的化学制造至关重要.
研究的目的:
- 提出一种新的,无金属的N-异环碳素 (NHC) 催化协议,用于合成MCOs.
- 建立一个原子经济和环保的替代传统的MCO合成.
主要方法:
- 在稀释氧化条件下利用N-异环碳素 (NHC) 催化,用于二甲和二醇的聚凝.
- 采用了绿色溶剂甲基四化 (Me-THF) 和可回收氧化剂.
- 研究了使用化石和生物基单体的MCOs的合成,包括2,5-二甲基 (DFF) 和2,5-二甲基 (BHMF).
主要成果:
- 实现了对MCOs的直接访问,避免有毒的二甲化.
- 合成了一系列新的和已知的MCOs,产量在51%-86%之间,与传统方法相比.
- 通过NMR和MALDI-TOFMS证明了该协议与各种单体的多功能性,并通过NMR和MALDI-TOFMS确认了结构.
结论:
- 该NHC催化方法提供了一个高效的,可持续的,无金属的通道到MCOs.
- 合成的宏循环是有价值的构建块,正如它们在热驱动的环开聚合 (ED-ROP) 中的成功应用所证明的那样.
- 通过ED-ROP优化了聚二二甲二二碳酸盐 (PBHMF) 的有机催化合成,实现了高分子量和产量.
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