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Updated: Jul 28, 2025

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结构和组件设计:新的策略调节基于脂质的纳米颗粒 in vivo 的行为

Qingguo Zhong1, Chunxiong Zheng1, Ke Yi1

  • 1Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. limq567@mail.sysu.edu.cn.

Biomaterials science
|May 30, 2023
PubMed
概括

基于脂质的纳米颗粒是先进的药物输送系统,在疫苗中有应用. 它们的结构和组成是有效传递,细胞进入和治疗效果增强的关键.

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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