与绝经后对照组相比,IV急性CRH给药在绝经后的PCOS妇女中显著增加了血清活性格林
Marios Markopoulos1, Thomas M Barber2, Alexandra Bargiota3
1Unit of Endocrinology, Diabetes Mellitus and Metabolism, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, "Aretaieion" University Hospital, Athens, Greece.
Endocrine
|May 30, 2023
概括
在患有多囊性卵巢综合征 (PCOS) 的绝经后妇女中,施用压力激素 (CRH) 会增加饥饿激素格林. 这表明一种适应机制可能导致PCOS患者的食欲增加.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 神经内分泌学神经内分泌学
背景情况:
- 多囊卵巢综合征 (PCOS) 与饮食失调和心理状态的改变有关.
- 急性压力会触发皮质激素释放激素 (CRH) 的分泌,这可能会影响食欲.
- 格林,一个关键的食欲调节激素,在PCOS和压力的背景下很有趣.
研究的目的:
- 在CRH刺激试验中,调查经更年期妇女患有PCOS的格林度.
- 探索PCOS中心理应激反应和食欲调节之间的关系.
主要方法:
- 20名患有PCOS的绝经后妇女和20名年龄/BMI匹配的对照妇女接受了静脉注射的CRH测试.
- 禁食血清活性格林水平在CRH给药后的多个时间点 (0-120分钟) 测量.
- 记录了人类测量测量,包括腰围.
主要成果:
- 绝经后的PCOS组表现出比对照组更高的腰围.
- 在PCOS组中,CRH的使用显著增加了活性格林,但在对照组中并非如此.
- 在基线和120分钟的对照组中,活性林水平显著更高,但在90分钟的PCOS组中更高.
- 在PCOS组中,活性格林的曲线下的三角形区域 (ΔAUCghr) 显着更大.
结论:
- 静脉注射CRH刺激了PCOS的绝经后妇女的活性林分泌.
- 这种反应可能代表PCOS的抗压适应机制.
- 在CRH刺激后升高的胆固醇可能会导致饥饿感增加作为副作用.
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