西班牙患有异常性肺纤维化病的经济负担:一个前性的真实世界数据研究 (OASIS研究)
Maria Jesus Rodríguez-Nieto1, Esteban Cano-Jiménez2, Ana D Romero Ortiz3
1Servicio de Neumología, IIS-Hospital Universitario Fundación Jiménez Díaz, CIBERES, Av. Reyes Católicos, 2, 28040, Madrid, Spain. mjrodriguezn@fjd.es.
PharmacoEconomics
|May 30, 2023
概括
异形性肺纤维化 (IPF) 显著增加医疗保健费用,特别是在肺功能较低的患者中. 早期疾病管理对于减少IPF的经济负担至关重要.
科学领域:
- 肺部医学 肺部医学
- 卫生经济学 卫生经济学
背景情况:
- 异形性肺纤维化 (IPF) 是一种进展性,致命的肺部疾病,影响生活质量.
- 在西班牙,IPF影响了大约7500名患者,其特点是呼吸障碍和咳.
研究的目的:
- 为了估计IPF在成年患者的经济影响.
- 分析基于强迫生命能力 (FVC) %预测水平的成本.
主要方法:
- 在西班牙进行的前性,观察性,多中心研究.
- 每名患者估计的每年IPF相关费用,按预测的FVC%分类 (<50%,50-80%,>80%).
- 使用医疗保健资源利用率和单位成本计算的直接和间接成本,更新至2023欧元.
主要成果:
- 包括180名IPF患者;平均年度成本为26,997.7欧元.
- 对于FVC<50% (44,412欧元) 的成本明显高于50-80% (25,803欧元) 和>80% (23,242欧元) 的成本.
- 肺功能受损 (FVC <50%) 和抗纤维素药物的使用导致更高的成本.
结论:
- 观察到较高的IPF年度成本,预测的FVC%较低.
- 直接成本,主要来自药物治疗,是最大的成本组成部分.
- 减缓IPF进展以维持早期疾病阶段是减少经济影响的关键.
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