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相关概念视频

Spermatogenesis01:41

Spermatogenesis

102.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.7K

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相关实验视频

Updated: Jul 28, 2025

Serial Enrichment of Spermatogonial Stem and Progenitor Cells SSCs in Culture for Derivation of Long-term Adult Mouse SSC Lines
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Serial Enrichment of Spermatogonial Stem and Progenitor Cells SSCs in Culture for Derivation of Long-term Adult Mouse SSC Lines

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展望:评估灵长类精子干细胞的方法

Sarah K Munyoki1, Kyle E Orwig2

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, Integrative Systems Biology Graduate Program, Magee-Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Methods in molecular biology (Clifton, N.J.)
|May 30, 2023
PubMed
概括
此摘要是机器生成的。

精子干细胞 (SSC) 是精子生产的关键. 高级灵长类动物的研究面临挑战,但在分离和移植这些细胞方面的进展为治疗男性不孕症提供了希望.

关键词:
阿达克阿达克是什么意思一个阿帕尔阿帕尔.接种 接种 接种人类人类人类.非人类灵长类动物.精子发生是精子生成.精子生病 (Spermatogonia) 是一种移植 移植 移植 移植

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A Standardized Approach for Multispecies Purification of Mammalian Male Germ Cells by Mechanical Tissue Dissociation and Flow Cytometry
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Separation of Spermatogenic Cell Types Using STA-PUT Velocity Sedimentation
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Separation of Spermatogenic Cell Types Using STA-PUT Velocity Sedimentation

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Serial Enrichment of Spermatogonial Stem and Progenitor Cells SSCs in Culture for Derivation of Long-term Adult Mouse SSC Lines
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A Standardized Approach for Multispecies Purification of Mammalian Male Germ Cells by Mechanical Tissue Dissociation and Flow Cytometry
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科学领域:

  • 生殖生物学和干细胞科学.
  • 研究哺乳动物的精子生成和干细胞应用.

背景情况:

  • 精子生成,即精子生产的过程,依赖于精子干细胞 (SSC).
  • 精子细胞具有独特的自我更新或分化能力,启动精子生产.
  • 对于男性不孕症的SSCs的治疗潜力是显著的.

研究的目的:

  • 为应对将动物SSC知识转化为高级灵长类动物 (子和人类) 的挑战.
  • 审查SSC在高级灵长类动物的表征,隔离,培养和移植方面的进展.
  • 克服对非人类灵长类动物和人类SSCs生物测试的局限性.

主要方法:

  • 高等灵长类动物中SSC的表征.
  • 开发用于隔离和培养灵长类SSCs的方法.
  • 在灵长类模型中评估SSC移植和功能.

主要成果:

  • 在了解灵长类的SSC生物学方面取得了进展.
  • 处理和繁殖灵长类SSC的技术正在进步.
  • 在建立灵长类的SSCs强大的体外和体内测试方面仍然存在挑战.

结论:

  • 将动物SSC研究转化为高级灵长类动物需要克服物种特定的术语和方法的差异.
  • 尽管面临挑战,但在表征,隔离,培养和移植灵长类SSC方面的进展是有希望的.
  • 进一步开发可访问的生物测试对于灵长类SSC在治疗男性不孕症的临床应用至关重要.