预防性上腺素和上腺素球,以预防剖腹产期间的脊柱后麻醉,降血压:一个随机的顺序分配剂量发现研究
Lei Guo1, Xiangzhao Xu2, Rui Qin1
1Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, People's Republic of China.
Drug design, development and therapy
|May 30, 2023
概括
预防性上腺素 (8微克) 和上腺素 (90微克) 在剖腹产麻醉期间有效预防低血压. 与上腺素相比,上腺素显示出较低的白心病发病率.
科学领域:
- 产科 产科 产科 产科 产科
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 上腺素和上腺素是产科麻醉中常见的血管压缩剂.
- 脊柱后麻醉低血压是剖腹产期间的一个重大问题.
研究的目的:
- 为了确定90 (ED90) 的有效剂量和预防性上腺素和上腺素球体的强度比.
- 为了比较这些药物在剖腹产期间预防低血压的疗效.
主要方法:
- 接受选择性剖腹产的80名患者被随机分配给接受预防性诺阿基尼林或基尼林玻尿酸剂.
- 使用上下序列分配方法来确定ED90,该方法基于防止静缩血压下降到基线的80%以下.
- 结果包括ED90,功效比,低血压发生率和不良事件.
主要成果:
- 上腺素的ED90为8.0μg (95%CI为7.1-11.0μg),而上腺素为90.9μg (95%CI为82.0-123.9μg).
- 相对强度比为11.4:1 (上腺素:上腺素).
- 勃拉迪心发生的频率较低,与诺拉上腺素 (2.5%对比20%,P=0.034).
结论:
- 预防性8μg的诺尔上腺素或90μg的上腺素丸子有效地预防剖腹产后脊髓麻醉的低血压.
- 上腺素对于这种适应症来说比上腺素更强大,并且与较少的胸肌梗塞有关.
相关概念视频
Local Anesthetics: Clinical Application as Epidural Anesthesia
461
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
461
Local Anesthetics: Clinical Application as Spinal Anesthesia
690
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
690
Aneurysm IV: Nursing Management
11
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
11
Parenteral Anesthetics: Overview
163
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
163
Cardiopulmonary Resuscitation IV: Pharmacological Management
30
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
30
Cardiomyopathy VII: Pre and Post Operative Nursing Management
16
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
16


