病例报告:CAR T细胞治疗后的CAR T细胞接受者的活跃结核病感染:一个追溯的病例系列
Peiling Zhang1,2, Liang Huang1,2, Miao Zheng1,2
1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Frontiers in cellular and infection microbiology
|May 30, 2023
概括
化学抗原受体 (CAR) T细胞疗法对B细胞癌症有希望,但存在活跃结核病 (TB) 的风险. 这项研究详细介绍了5个结核病后CAR T细胞治疗的病例,强调了各种表现和治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 传染性疾病 传染性疾病
背景情况:
- 化学抗原受体 (CAR) T细胞疗法,特别是针对CD19和CD22,在治疗B细胞恶性瘤方面表现出高疗效.
- 新出现的证据表明,新型免疫疗法与活性结核病 (TB) 的重新激活或发展之间存在潜在的关联.
- 在接受CAR T细胞治疗的患者中,关于结核病的发病率和临床特征的数据有限.
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