益生菌治疗显示,肥胖和神经行为障碍症状显著改善
Yichen Cai1, Pan Liu1, Xiaolan Zhou1
1Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in cellular and infection microbiology
|May 30, 2023
概括
益生菌可以通过调节肠-大脑轴来改善与肥胖有关的认知功能,焦虑和抑郁. 然而,要小心使用益生菌,因为研究仍在进行中.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 肥胖是一种复杂的代谢疾病,经常伴随着认知障碍.
- 肠道微生物群在微生物-肠道-大脑轴中发挥着至关重要的作用,影响大脑功能.
- 益生菌在管理与肥胖相关的神经行为障碍方面显示出潜力.
研究的目的:
- 审查关于益生菌干预认知障碍,抑郁症和肥胖焦虑症的现有研究.
- 在肥胖的背景下,评估益生菌对肠-大脑轴的影响.
主要方法:
- 对先前发表的研究进行系统审查.
- 对肥胖相关认知和情绪障碍中的益生菌有效性研究的分析.
主要成果:
- 大多数研究的益生菌对肥胖引起的认知障碍和焦虑产生有益影响.
- 益生菌积极影响免疫调节,下丘脑-垂体-上腺轴和海马体功能.
- 益生菌会影响肠道微生物群的组成和葡萄脂代谢.
结论:
- 益生菌有望缓解与肥胖相关的认知缺陷和焦虑.
- 需要进一步的研究来澄清机制并解决研究设计的局限性.
- 建议在使用益生菌时谨慎使用,特别是在健康人群中.
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