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一种新的重新分类型H3N6犬流感病毒的出现

Bo Meng¹, Hailing Li¹, Chong Feng¹

¹Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.

Frontiers in microbiology

|May 30, 2023

概括

在中国,狗流感病毒 (CIV) 通过重组和突变快速演变. 新型H3N6 CIV显示哺乳动物适应性增加,突出显示了狗病毒进化的潜力.

科学领域:

兽医病毒学兽医病毒学
分子流行病学分子流行病学
动物传染病监测动物传染病监测

背景情况:

禽流感病毒 (AIV) 可以蔓延到哺乳动物宿主,可能适应人类传播.
由于与人类的密切接触,狗可以作为AIV适应的中间宿主.
对狗流感病毒 (CIV) 的监测对于了解病毒演变和动物感染潜力至关重要.

研究的目的:

在中国宁研究犬流感病毒 (CIV) 的流行病学和演变.
识别新型CIV亚型并评估它们对哺乳动物的适应性.
了解CIV进化的机制,包括重组和遗传突变.

主要方法:

在中国宁市对狗进行了三次CIV监测调查 (2018年11月,2019年3月,2019年4月).
隔离和特征化犬流感H3N2和新型H3N6病毒菌株.
进行了体外和体内研究,以比较H3N6和H3N2 CIVs在哺乳动物中的适应性.
分析了基因序列,以调查AIVs的潜在重组事件.

主要成果:

隔离了五种H3N2和七种新型H3N6 CIV菌株.
确定了H3N2 CIVs和H5N6 AIVs之间重新分类的高可能性,导致H3N6 CIVs.
与H3N2菌株相比,在H3N6CIV中证明了哺乳动物适应性增加.
在研究期间晚些时候分离的H3N2 CIV中观察到增强的复制效率,表明正在进行的进化.

结论:

在中国,狗流感病毒 (CIVs) 通过基因突变和重组迅速演变.
新型H3N6 CIV表现出增强的哺乳动物适应性,这表明进一步适应的潜力.
狗是CIV进化的重要宿主,需要持续监测和研究.

关键词:

这种病毒是H3N2的.H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 H5N6 狗流感病毒狗流感病毒狗流感病毒重组组合剂重新组合剂复制能力的复制能力.

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