用于治疗性免疫调节的细胞纳米纤维:对工程战略和新进展的视角
Endong Zhang1, Philana Phan1, Zongmin Zhao1,2
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, USA.
Acta pharmaceutica Sinica. B
|May 30, 2023
概括
细胞纳米纤维,微小的细胞衍生结构,显示出免疫调节的前景. 这些纳米纤维可以提供治疗分子,为各种疾病提供新的无细胞免疫疗法.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 纳米医学是一种纳米医学.
背景情况:
- 细胞纳米纤维是来自细胞的纳米化脂质双层结构.
- 它们具有很高的生物相容性,结构稳定性和各种分子的负载能力.
- 这些特性使它们适合提供免疫调节剂.
研究的目的:
- 审查使用细胞纳米纤维用于免疫反应调节的新兴概念和进展.
- 解释它们在免疫调节中的应用.
- 讨论工程纳米纤维与定制活动的设计原则.
主要方法:
- 关于细胞纳米纤维和免疫调节的当前文献的综述.
- 对工程纳米纤维用于治疗输送的策略的分析.
- 讨论在疾病治疗中的应用.
主要成果:
- 细胞纳米纤维可以激活或抑制免疫反应.
- 它们作为一种新的无细胞免疫治疗策略.
- 工程纳米纤维提供量身定制的免疫调节活动.
结论:
- 细胞纳米纤维是免疫调节的一个有希望的平台.
- 它们的工程形式正在推进各种疾病的无细胞免疫疗法.
- 对其设计和应用的进一步研究具有显著的治疗潜力.
相关概念视频
01:29Microorganisms in Medicine and Therapeutics
74
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
74
01:27Tumor Immunotherapy
577
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
577
01:27Cytotoxic T Cells-mediated Immune Response
1.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.0K