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多发性硬化症的纵向嗅觉模式:范围审查和用于疾病管理的含义
Lauren L Todd1, Ram Sivakumar1, Sharon G Lynch2
1From the School of Medicine (LLT, RS), University of Kansas Medical Center, Kansas City, KS, USA.
International journal of MS care
|May 30, 2023
概括
嗅觉功能障碍 (OD) 在多发性硬化症 (MS) 中很常见. 纵向研究表明,OD变化与MS炎症和神经退行相关,这表明它在疾病监测中的潜在作用.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 眼科医生 眼科 眼科
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 嗅觉功能障碍 (OD) 是MS患者的一种已知的症状.
- 现有的审查缺乏对MS和OD的纵向研究的重点.
研究的目的:
- 审查研究多发性硬化症和嗅觉功能障碍之间的关系的纵向研究.
- 探索嗅觉功能障碍在MS诊断和预后中的作用.
主要方法:
- 进行了对纵向研究的范围审查.
- 在多个科学数据库中进行了系统搜索.
- 包括研究MS和纵向嗅觉的研究.
主要成果:
- 九项研究符合纳入标准,重点关注复发性复发性或进展性MS.
- 患有多发性硬化症的患者始终表现出增加的嗅觉功能障碍.
- 纵向分析显示了两个模式:与较高的气味值相关的急性炎症,与受损的气味区分/识别相关的神经退行.
结论:
- 嗅觉是MS的一个动态变量,受神经退行和炎症的影响.
- 嗅觉功能的变化与MS进展的临床标志物相关.
- 嗅觉可以作为未来的MS诊断,特征和治疗反应的生物标志物.
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