相关实验视频

Updated: Jul 28, 2025

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

微粒物质 (PM_2.5) 的毒理影响:健康风险和相关的系统性损伤-系统性审查

Amanda Garcia^1,2, Eduarda Santa-Helena^1,2,3, Anna De Falco³

¹Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS Brazil.

Water, air, and soil pollution

|May 30, 2023

概括

颗粒物 (PM2.5) 暴露会损害人类多个器官系统,包括心血管,呼吸,和神经系统. 这次审查突出了PM2.5的重点.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

气动直径≤2.5μm (PM2.5) 的颗粒物与增加疾病风险,发病率和死亡率有关.
以前的研究主要集中在PM2.5.5对心血管和呼吸系统的影响上.
新出现的证据表明,PM2.5暴露对人类健康的系统性影响更广泛.

研究的目的:

通过审查2016-2021年的流行病学和实验发现,提供PM2.5对人类健康的有毒影响的系统概述.
调查PM2.5暴露,系统性影响和COVID-19疾病之间的相互作用.
确定有关PM2.5对人类健康有害影响的知识差距.

主要方法:

2016年至2021年间发表的流行病学和实验研究的系统审查.
在科学网络数据库上进行文献搜索,使用PM2.5暴露,系统性影响和COVID-19的描述性术语.
对聚焦PM2.5,人体器官系统和SARS-CoV-2之间的相互作用的研究分析.

主要成果:

暴露于PM2.5显著影响心血管和呼吸系统,与之前的研究一致.
PM2.5还会对脏,神经,胃肠道和生殖系统产生不利影响.
包括炎症,氧化应激和基因毒性在内的毒理学影响有助于器官功能障碍和病理发病/恶化.
评估了COVID-19/SARS-CoV-2和PM2.5暴露之间的相关性,这表明空气污染在疾病病理生理学中的作用.

结论:

暴露于PM2.5对心血管和呼吸道以外的多个人体器官系统构成重大威胁.
了解PM2.5毒性的机制对于公共卫生干预至关重要.
需要进一步的研究,以充分阐明PM2.5暴露,全身健康和COVID-19等传染病之间的复杂相互作用.

关键词:

疾病疾病疾病炎症炎症是一种炎症.氧化应激是一种氧化应激.颗粒物质颗粒物质是什么系统系统系统系统有毒性有毒性

更多相关视频

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Published on: December 21, 2016

相关概念视频

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

The Periodic Table and Organismal Elements

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...