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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Updated: Jul 28, 2025

Author Spotlight: Insight Into Advances in Prion Diseases Research
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在鼻腔内输送的介质细胞 stromal 细胞降低质体炎症早期的普里翁病.

Arielle J D Hay1,2, Amanda S Latham2,3, Genova Mumford1,2

  • 1Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Frontiers in neuroscience
|May 30, 2023
PubMed
概括
此摘要是机器生成的。

在内脂肪衍生的中细胞 (AdMSCs) 减少神经炎症和星病在小鼠模型的病. 虽然没有延长生存期,但AdMSC治疗调节了微质状态并降低了炎症基因表达.

关键词:
星球细胞是星球细胞.细胞因子 细胞因子这是一种炎症炎症炎症炎症.介质细胞层细胞.微质细胞中的微质细胞普里昂是什么意思?普里昂是什么意思?

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科学领域:

  • 神经科学是一个神经科学.
  • 再生医学是一种再生医学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 介酶体 stromal 细胞 (MSCs) 通过迁移到神经炎症部位,显示出治疗神经系统疾病的潜力.
  • 子病是一种致命的神经退行性疾病,其特点是蛋白质错折,神经炎症和神经元损失.

研究的目的:

  • 在子病的小鼠模型中研究通过鼻腔输送的脂肪衍生MSCs (AdMSCs) 的疗效.
  • 评估AdMSC治疗对神经炎症,微质激活和星病的影响.

主要方法:

  • 用瘤亡因子α (TNFα) 或子感染的大脑同源体刺激AdMSCs.
  • 每两周一次的鼻内AdMSC输送给以子接种的小鼠.
  • 分析了基因表达,真空化,微质状态和天体细胞形态.

主要成果:

  • 治疗AdMSC降低了真空化,并抑制了核因子-kappa B (NF-κB) 和海马中的NLRP3炎症酶信号.
  • AdMSCs诱导了微质中的静止状态,并减少了星球细胞的数量和反应性.
  • 治疗并没有延长存活时间或拯救神经元.

结论:

  • 鼻内AdMSC的输送有效地对抗神经炎症和星病在普里昂病小鼠模型中.
  • AdMSCs对微质细胞和星球细胞表现出免疫调节作用,减少了疾病病理.
  • 进一步的研究是有必要的,以探索使用MSCs治疗子疾病的治疗策略.