在整个轴性脊柱关节炎谱中使用secukinumab的现实世界经验
Francisca Sivera1,2, Victoria Núñez-Monje3, Cristina Campos-Fernández4
1Rheumatology Department, Hospital General Universitario de Elda, Alicante, Spain.
Frontiers in medicine
|May 30, 2023
概括
在现实环境中,secukinumab有效治疗轴性脊柱关节炎 (axSpA),改善疾病活性并保持高的持续率,特别是在生物素的患者中.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 塞库金纽马布是一种有效的生物修饰疾病的抗风湿药物 (bDMARD) 用于轴性脊柱关节炎 (axSpA).
- 关于secukinumab在axSpA中的有效性和持久性的现实数据有限.
- 这项研究提供了关于在axSpA患者中使用secukinumab的真实证据.
研究的目的:
- 为了评估sequukinumab在axSpA患者中的实际有效性.
- 评估secukinumab在axSpA.不同治疗线上的持久性.
- 收集 axSpA. axSpA. 在临床实践中使用secuquinumab 的数据.
主要方法:
- 对221名axSpA患者进行了回顾性多中心研究,这些患者接受了secukinumab治疗.
- 在BASDAI收集的数据,疼痛和全球评估长达24个月.
- 根据治疗线路 (第一,第二,≥第三) 和患者持久性进行分析.
主要成果:
- 在长达24个月的时间里,secukinumab显著改善了疾病活动 (BASDAI,疼痛,全球评估).
- 没有生物素的患者表现出最大的BASDAI改善.
- 整体24个月的持续率为58%,在一线患者中最高.
结论:
- 在现实临床实践中,secukinumab在改善axSpA疾病活性方面表现出有效性.
- 特别值得注意的是,在生物素素和二线患者中,疗效尤为显著.
- 高持续率支持sequukinumab在axSpA管理中的长期效用.
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