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化疗期间体力活动对癌症幸存者的认知功能的影响:系统性审查和元分析
Physiotherapy Canada. Physiotherapie Canada
|May 30, 2023
概括
在化疗期间进行体力活动可能会改善癌症幸存者的社会认知能力. 这次元分析发现,有氧和抵抗训练的组合有益,尽管由于证据质量,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 神经科学是一个神经科学.
背景情况:
- 癌症化疗往往导致认知障碍,影响幸存者的生活质量.
- 身体活动 (PA) 被探索为减轻化疗诱导的认知功能障碍的潜在干预措施.
- 了解PA在治疗期间对认知功能的影响对于支持性护理至关重要.
研究的目的:
- 评估同时进行体力活动对接受化疗的癌症幸存者的认知功能的影响.
- 综合从评估这一群体认知结果的定量研究中得到的证据.
主要方法:
- 在多个电子数据库 (Ovid MEDLINE,Embase,CINAHL,PsycINFO,AMED) 进行了系统的文献搜索,截至2020年2月.
- 包含的研究是定量性的,重点是接受化学疗法并接受PA干预的成年癌症患者.
- 使用已知工具 (Cochrane's RoB 2,ROBINS-I,Newcastle-Ottawa) 评估了偏差风险,并使用标准化平均差异 (SMD) 进行了元分析.
主要成果:
- 22项研究,包括15项随机对照试验 (RCT) 和7项非RCT,符合纳入标准.
- 一项元分析显示,与常规护理相比,联合抵抗和有氧运动显著改善了社会认知 (SMD 0.23;95% CI:0.04,0.42;p=0.020).
- 观察到的效应大小小小,但在统计学上是显著的.
结论:
- 联合抵抗和有氧运动可能为接受化疗的癌症幸存者提供社会认知的好处.
- 目前的证据基础具有偏见和低质量的高风险,需要进一步严格调查.
- 对这一群体的具体体育活动建议需要额外的支持性研究.
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