在体外,Mycobacterium manresensis会诱导训练有素的免疫
Miquel de Homdedeu1,2,3, Lidia Sanchez-Moral1, Concepció Violán4,5,6,7,8
1Innate Immunity Group, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain.
iScience
|May 30, 2023
概括
热杀死的Mycobacterium manresensis在实验室环境中诱导了训练有素的免疫力,但在临床试验中未能防止SARS-CoV-2感染. 口服Nyaditum resae并没有在医疗保健工作者中预防COVID-19.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行仍然是一个全球健康问题.
- 新出现的SARS-CoV-2变种挑战了疫苗的有效性.
- 训练免疫提供了一种潜在的策略,可以增强对感染的先天免疫反应.
研究的目的:
- 调查热杀死的Mycobacterium manresensis (hkMm) 是否可以诱导训练免疫力.
- 评估hkMm对SARS-CoV-2感染的保护潜力.
- 在人类临床试验中评估含有 hkMm 的 Nyaditum resae (NR) 的疗效.
主要方法:
- 在体外研究中,使用与hkmm训练的THP-1细胞和初级单细胞进行了实验.
- 对细胞因子分泌 (TNF-α,IL-6,IL-1β,IL-10),代谢活性和表观遗传修饰的分析.
- 一个随机的,安慰剂控制的临床试验 (MANRECOVID19) 在医疗保健工作者每天给NR或安慰剂14天.
主要成果:
- 在体外,hkMm诱导训练免疫,其特征是炎症性细胞因子的产生增加,代谢活动增强和表观遗传标记的改变.
- 在MANRECOVID19试验中,NR和安慰剂组之间没有观察到单细胞炎症反应或SARS-CoV-2感染发病率的显著差异.
- 每天口服NR14天,尽管改变了循环免疫细胞种群,但并没有在体内给予对SARS-CoV-2感染的保护.
结论:
- 在体外,Mycobacterium manresensis会诱导训练的免疫力.
- 在14天内口服Nyaditum resae (hkMm) 不会诱导受训免疫力或在体内防止SARS-CoV-2感染.
- 需要进一步的研究,以探索利用训练有素的免疫力对抗病毒感染的替代策略.
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