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围部植入物形态和稳定性在骨愈合中的物质依赖性

Stefan Bruns¹, Diana Krüger¹, Silvia Galli²

¹Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, 21502, Geesthacht, Germany.

Bioactive materials

|May 30, 2023

概括

生物材料的选择会影响植入物周围的骨愈合. 能促进强壮的骨形成,而-加多合金表现出不那么有序的菌株转移,影响植入物稳定性和材料选择.

科学领域:

生物材料科学生物材料科学
生物力学生物力学
整形外科的研究研究.

背景情况:

周围植入物骨的微观结构结构对于应变能量分布和螺丝植入物稳定性至关重要.
了解不同生物材料如何影响骨重塑和机械整合对于成功的骨科应用至关重要.

研究的目的:

为了研究,聚乙基 (PEEK) 和可生物降解-加多 (Mg-Gd) 合金螺丝植入物对大鼠骨模型周植入物骨改造和机械稳定性的影响.
分析骨形态,菌株转移和植入物稳定性在植入后的不同时间点.

主要方法:

螺丝植入物 (,PEEK,Mg-Gd合金) 被插入老鼠的小腿骨中.
在植入后4,8周和12周进行了推出测试.
使用同步辐射微计算机断层扫描 (5微米分辨率) 和数字体积相关性 (DVC) 来评估骨变形,应变和形态.

主要成果:

可生物降解的Mg-Gd合金植入物显示稳定性与简单的针相比,而不可降解的材料提供了增强的机械稳定性.
植入物诱导了快速的形形成,并具有一致的菌株形状.
Mg-Gd合金植入物导致在接口附近的骨体积分数较低,菌株转移的顺序较差.

结论:

周围植入物骨形态和菌株转移受到使用的生物材料的重大影响.
植入物稳定性与特定的骨形态特性有关,这些特性因生物材料而异.
骨科植入物生物材料的选择应根据具体的临床情况和局部组织特征进行量身定制.

关键词:

可生物降解的植入物材料骨机械测试骨机械测试骨机械测试数字体积相关性数字体积相关性植入物稳定性植入物稳定性同步机微型计算机断层扫描成像.

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