关于NAFLD名称变更为MAFLD的INASL-SAASL共识声明
Shivaram P Singh1, Ajay Duseja2, Mamun Al Mahtab3
1Kalinga Gastroenterology Foundation, Cuttack 753001, Odisha, India.
Journal of clinical and experimental hepatology
|May 30, 2023
概括
关于将非酒精性脂肪性肝病 (NAFLD) 改为代谢相关脂肪性肝病 (MAFLD) 的辩论仍在继续. 专家建议仔细考虑更改名称.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 临床命名法 临床命名法
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 术语正在讨论中,2020年建议将其更改为代谢相关脂肪性肝病 (MAFLD).
- 拟议的MAFLD命名体系旨在更好地反映当前对该疾病的理解.
- 人们担心MAFLD提案缺乏关键利益相关者的全球代表性.
研究的目的:
- 评估将NAFLD更名为MAFLD的适当性.
- 收集印度国家肝脏研究协会 (INASL) 和南亚肝脏研究协会 (SAASL) 的专家意见.
- 制定关于拟议的命名规范变更的建议.
主要方法:
- 在2022年3月,INASL和SAASL专家的共识会议举行.
- 根据系统的文献审查和专家审议,制定了建议.
- 对于最终的建议,采用了名义投票技术,使用推,评估,开发和评估等级系统评估证据质量.
主要成果:
- 拟议的MAFLD术语可能不完全涵盖脂肪肝疾病的复杂性和全球患者的观点.
- 来自南亚肝脏协会的专家共识表明,在采用MAFLD命名表之前,需要进行更广泛的咨询.
- 该过程涉及系统审查和严格投票,以确保强有力的建议.
结论:
- 建议从NAFLD更改为MAFLD需要进一步审议,因为它可能对患者护理和全球代表性产生影响.
- 建议强调谨慎对待肝脏疾病的命名变化.
- 进一步的研究和更广泛的利益相关者参与对于任何未来的术语修订至关重要.
相关概念视频
Lipid Digestion
92.3K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
92.3K
Overview of Fatty Acid Metabolism
30.9K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.9K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
717
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
717
Diseases of the Liver and Gallbladder
705
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
705
Ultrasound II: Endoscopic Ultrasound and FibroScan
150
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
150
Atherosclerosis III: Management
16
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16


