低频波动的动态幅度被破坏,在患有活跃甲状腺相关眼科医症的患者中
Zhi Wen1, Yan Kang2,3, Yu Zhang1
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in cell and developmental biology
|May 30, 2023
概括
甲状腺相关的眼科医疗 (TAO) 改变了本地大脑活动动态,特别是在视觉处理区域减少dALFF. 动态大脑活动中的这些变化可能为TAO病原体提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺相关眼病 (TAO) 是一种与格雷夫斯病相关的自身免疫轨道疾病.
- 现有的TAO神经成像研究主要检查静态大脑活动和功能连接.
- 在TAO患者中,局部大脑活动的动态变化仍未得到充分研究.
研究的目的:
- 研究活跃TAO患者的低频波动 (dALFF) 动态振幅的变化.
- 使用dALFF模式将TAO患者与健康对照 (HC) 区分开来.
- 为了探索dALFF对TAO的诊断潜力.
主要方法:
- 在休息状态功能磁共振成像 (fMRI) 进行了21名TAO患者和21名HC患者.
- 使用滑窗技术计算和分析dALFF,评估动态区域大脑活动.
- 使用支持矢量机 (SVM) 分类器来评估dALFF地图的诊断准确性.
主要成果:
- 与HC患者相比,活跃的TAO患者在右骨,舌环,上叶片和前骨中表现出减少的dALFF.
- 在将TAO与HC区分时,SVM模型的准确性 (45.24%-47.62%) 和AUC (0.35-0.44) 是有限的.
- 在临床变量和区域dALFF值之间没有观察到显著的相关性.
结论:
- 活性TAO与视觉皮层和相关视觉通路中的改变dALFF有关.
- 这些发现有助于更深入地了解TAO的神经生物学基础和病原性.
- 动态大脑活动模式,特别是在视觉网络中,可能与TAO相关.
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