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在纳米药物交付中克服内体/淋巴体障碍的先进策略

Chong Qiu¹, Fei Xia¹, Junzhe Zhang¹

¹Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Research (Washington, D.C.)

|May 30, 2023

概括

纳米载体增强药物输送,但面临内体/溶体降解. 本综述探讨了一些策略,比如促进有效的纳米药物输送系统的逃生和替代途径.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

纳米载体有望提供多种疗法,包括生物制剂,小分子和核酸.
纳米载体有效性的一个主要限制是细胞通过内细胞分裂吸收后,内/溶体内的降解.

研究的目的:

审查在纳米药物输送中克服内体/解体障碍的先进策略.
提供有关纳米载体设计的细胞吸收和细胞内运输机制的见解.
为改善临床应用的纳米药物输送系统提出未来的方向.

主要方法:

文献综述侧重于细胞吸收和细胞内运输机制.
分析增强细胞内纳米载体生存的策略.
确定绕过或克服内体/溶体退化的方法.

主要成果:

策略包括促进内体/溶体逃生.
非内细胞传递方法提供直接的细胞膜穿越,绕过内体/溶体.
可以利用替代的细胞内运输途径来避免降解.

结论:

克服内体/溶体壁垒对于有效的纳米药物输送至关重要.
采用这些策略的更智能纳米药物输送系统设计可以改善治疗结果.
拟议的策略对未来纳米药物的临床转化具有前景.

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