爱尔兰的ANCA相关血管炎:一个多中心的国家队列研究
Jennifer Scott1, Eithne Nic An Ríogh1, Shamma Al Nokhatha1
1Trinity Health Kidney Centre, Trinity College Dublin, The University of Dublin, Dublin, D02 PN40, Ireland.
HRB open research
|May 30, 2023
概括
抗中性细胞质抗体 (ANCA) 相关血管炎 (AAV) 患者的存活率与其他系列相比较. 基线功能障碍和不良事件预测死亡,而功能衰竭,usCD163和组织学预测末期病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 反中性细胞质抗体 (ANCA) 相关的血管炎 (AAV) 是一种罕见的自身免疫性疾病.
- 需要国家注册表来跟踪AAV的长期结果.
- 爱尔兰国家罕见病 (RKD) 登记处收集有关血管炎患者的数据.
研究的目的:
- 分析患者和疾病特征,治疗和AAV患者队列中的结果.
- 在AAV.中确定死亡率和末期病 (ESKD) 的预测因素.
- 评估尿溶性CD163 (usCD163) 作为ESKD风险的生物标志物的实用性.
主要方法:
- 预计将397名AAV患者招募到爱尔兰RKD登记处.
- 对患者人口统计,疾病类型,功能障碍和治疗的分析.
- 统计分析以确定患者存活率和ESKD的预测因素.
主要成果:
- 平均年龄为64岁,57.9%是男性,58.9%是微观多炎,85.9%是功能障碍.
- 一年和五年患者的生存率分别为94%和77%.
- 基线功能障碍和不良事件预测死亡;功能不足,usCD163,和组织学预测ESKD.
结论:
- 爱尔兰AAV患者的长期结果与国际数据可比.
- 个性化免疫抑制对于限制患有功能衰竭的老年患者的毒性至关重要.
- 基线usCD163显示出作为ESKD生物标志物的潜力,需要进一步验证.
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