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与雌激素反应相关的特征预测了黑色素瘤免疫治疗的反应

Min Lin¹, Tian Du², Xiaofeng Tang¹

¹Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China.

Frontiers in immunology

|May 30, 2023

概括

我们确定了一个11个基因的签名,预测黑色素瘤的免疫治疗反应,与免疫细胞透有关. 向雌激素通路可能会提高黑色素瘤免疫疗法的疗效.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

雌激素受体信号影响瘤微环境和黑色素瘤免疫治疗的有效性.
了解这些相互作用对于改善治疗结果至关重要.

研究的目的:

开发基于雌激素反应途径的基因特征,以预测黑色素瘤的免疫治疗反应.
为了将这种特征与免疫细胞透和临床结果相关联.

主要方法:

利用了来自四个免疫治疗黑色素瘤队列的RNA测序数据和TCGA黑色素瘤数据.
进行差异表达和途径分析,以确定与雌激素反应相关的基因,将响应者与非响应者区分开来.
使用11个差异表达基因构建了一个多变量逻辑回归模型,以预测免疫治疗反应.

主要成果:

确定了11个基因的特征,在训练组中AUC为0.888,在验证组中为0.654-0.720.
较高的签名得分与增加的CD8+T细胞透率相关 (rho=0.32,p=0.02).
在TCGA黑色素瘤中,高特征得分与免疫丰富的微环境亚型和更好的无进展生存率相关 (p=0.021).

结论:

一个11个基因的签名有效地预测了黑色素瘤的免疫治疗反应,并与瘤透的淋巴细胞相关联.
向与雌激素相关的途径是增强黑色素瘤免疫疗法的潜在组合策略.

关键词:

雌激素雌激素雌激素是一种基因签名基因签名基因签名免疫检查点封锁封锁黑色素瘤是一种黑色素瘤.瘤透的淋巴细胞

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