儿科急性发病神经精神综合征:当前前景观
Antonella Gagliano1,2, Alessandra Carta3, Marcello G Tanca2
1Department of Health Science, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
儿科急性发病神经精神综合征 (PANS) 涉及突然的神经精神症状,通常与免疫相关. 本综述详细介绍了PANS的临床和病理生理方面,以帮助诊断和管理.
科学领域:
- 儿科神经学 儿科神经学
- 神经精神病学是一种神经精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 儿科急性发病神经精神综合征 (PANS) 呈现出急性强迫症,饮食问题和行为变化,可能导致认知能力下降.
- 提出一种免疫媒介病因,涉及致病原驱动的自身免疫反应,影响中枢神经系统 (CNS).
研究的目的:
- 审查PANS中最近的临床和病理生理学发现.
- 为医疗保健从业人员提供管理PANS的指导.
- 探索PANS,自身免疫性脑和精神疾病之间的关系.
主要方法:
- 一个讲述英语书面,全文临床研究,病例报告和评论的叙事评论.
- 在PubMed数据库上进行文献搜索.
- 从最初的1005篇文章中,包括了205篇相关文章.
主要成果:
- PANS越来越多地被视为感染后或与压力相关的"脑炎"现象.
- 将PANS与自身免疫性脑和精神疾病区分开来,揭示了显著的重叠.
- 有限的随机对照试验阻碍了最终的治疗等级协议.
结论:
- 需要一个全面的PANS诊断和治疗算法.
- 目前的PANS管理结合了免疫调节,抗炎药物,精神药物和行为疗法.
- 神经炎症可能是各种精神病现象的共同基质,包括PANS.
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