IGFBP1表达与癌症风险之间的关联:系统性审查和元分析
Biao Zhang1,2, Chao-Qun Hong3, Yi-Wei Lin1,3
1Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Heliyon
|May 30, 2023
概括
这次元分析发现,高胰岛素样生长因子结合蛋白1 (IGFBP1) 表达与前列腺癌和结直肠癌 (CRC) 的风险降低有关. 需要进一步的研究来证实这些关于IGFBP1和癌症风险的发现.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 胰岛素类生长因子结合蛋白1 (IGFBP1) 表达和癌症风险之间的关系产生了有争议的结果.
- 之前的研究已经产生了关于IGFBP1在癌症发展中的作用的相互矛盾的证据.
研究的目的:
- 进行元分析,调查IGFBP1表达与各种癌症风险之间的关联.
- 为IGFBP1与癌症发病率之间的联系提供最新证据.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和科学网上进行了全面的文献搜索.
- 包括检查IGFBP1表达和癌症风险的队列和病例控制研究.
- 使用随机效应模型将几率比率 (ORs) 结合起来,并进行子组分析.
主要成果:
- 分析包括27项研究 (16个队列,11个病例控制).
- 总的来说,IGFBP1表达与各种癌症的风险之间没有发现显著的关联 (OR:0.90,95%CI:0.791.03).
- 然而,高IGFBP1表达与前列腺癌 (OR:0.71,95% CI:0.570.88) 和结直肠癌 (CRC) (OR:0.66,95% CI:0.440.99) 的风险降低有关.
结论:
- 高IGFBP1表达与前列腺癌和CRC风险降低有关.
- 在卵巢,乳腺,子宫内膜,肺癌,结肠直肠腺瘤或多发性髓瘤方面没有观察到显著的关联.
- 需要进一步的研究来证实IGFBP1在特定癌症中的保护作用.
相关概念视频
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancer-Critical Genes I: Proto-oncogenes
9.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K


