在治疗胃肠道恶性瘤的基于牛利的化疗期间倒 - (从中吸取的教训) 一项前性研究
Melanie Galliardt1,2, Ulrich Betz3, Frank Birklein1
1Department of Neurology, University Medical Center, Johannes-Gutenberg-University, Mainz, Germany.
Open medicine (Warsaw, Poland)
|May 30, 2023
概括
以前存在的跌倒风险因素,而不是化疗,更频繁地导致患者跌倒. 跌倒风险指数是门诊瘤诊所的有效查工具.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 基于奥克萨利普拉丁的化疗可以引起神经毒性副作用,包括化疗诱导的神经病变.
- 化疗诱导的神经病变可能会影响功能性跌倒风险,并增加正在接受治疗的患者跌倒的可能性.
研究的目的:
- 描述基于oxaliplatin的化疗及其神经毒性副作用对功能性跌倒风险和跌倒的影响.
- 评估跌倒风险指数在门诊瘤环境中进行查的有用性.
主要方法:
- 一项前性队列研究,包括20名化学疗法初学者参与者.
- 在6个月内使用功能测试 (Tinetti,椅子抬起,定时上升和去) 和神经障碍量表进行多式跌倒风险评估.
- 患者报告的结果包括焦虑,抑郁 (HADS),跌倒恐惧 (FES-I) 和体力活动 (PASE).
主要成果:
- 发生了三次跌倒;所有跌倒的参与者都有高跌倒风险指数 (≥4个风险因素) 和先前存在的轻度多神经病变 (p=0.03,p=0.049).
- 研究中断 (n=12) 与多药,焦虑 (HADS-A) 和跌倒恐惧 (FES-I) (p=0.045,p=0.03,p=0.025) 有关.
- 研究完成者 (n=8) 显示身体活动改善 (PASE) (p=0.018).
结论:
- 以前存在的跌倒风险因素对跌倒的影响比化疗本身更大.
- 跌倒风险指数提供了一种时间效率高,有效的查方法,用于在门诊瘤学中发现跌倒风险.
- 对于接受化疗的患者来说,早期识别和管理跌倒风险因素至关重要.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
07:54Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
18.7K
相关概念视频
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
256
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
256
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
581
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
581
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
210
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
210