尿路感染中微生物群水平的变化:一个元分析
Xia Weng1, Yajun Liu2, Haiping Hu1
1Urology Department, Zhejiang Hospital, Hangzhou 310013, Zhejiang Province, China.
Open medicine (Warsaw, Poland)
|May 30, 2023
概括
尿路感染 (UTI) 患者表现出较低的微生物群多样性和增加的特定细菌,特别是大肠杆菌,而乳酸菌水平下降. 这些发现表明,尿路感染治疗的潜在微生物群标志物.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物信息学是一种生物信息学.
背景情况:
- 微生物群在尿路感染中的作用缺乏明确的共识.
- 了解微生物社区的变化对于诊断和治疗尿路感染至关重要.
研究的目的:
- 对现有研究进行元分析,以确定微生物群水平与尿道感染之间的关系.
- 确定潜在的微生物生物标志物用于尿路感染诊断和治疗.
主要方法:
- 在PubMed,Web of Science和Embase数据库进行系统的文献搜索,截至2021年10月20日.
- 使用随机效应模型对微生物群多样性和丰富性的标准化平均差异 (SMD) 的元分析.
- 包括12项研究,将尿路感染患者与健康个体进行比较.
主要成果:
- 与健康对照人群相比,尿路感染患者的微生物群多样性明显较低 (SMD = -0.655).
- 在尿路感染患者 (SMD = 0.41) 中,总体细菌丰度更高,特别是在北美队列和研究中,参与者>30.
- 具体发现包括尿路感染患者增加的大肠杆菌和减少的乳酸菌水平.
结论:
- 尿路感染与微生物多样性减少和细菌丰度改变有关.
- 增加的大肠杆菌和减少的乳杆菌水平显示出作为尿路感染的潜在生物标志物具有前途.
- 对这些微生物标记物的进一步研究可以为尿路感染提供新的治疗策略.
相关概念视频
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