液体 - 固体合模型和大前置水道综合征的生物学特征
Zewen Chen1, Mengjie Luo1, Can Zhou1
1Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in bioengineering and biotechnology
|May 30, 2023
概括
大前庭水道综合征 (LVAS) 涉及内耳的结构变化. 使用3D模型进行的生物机械分析表明,较大的前庭水道 (VA) 缩小了内耳.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 计算力学 计算力学 计算力学
背景情况:
- 大前庭水道综合征 (LVAS) 是儿童感觉神经听力损失的常见原因.
- 虽然LVAS的病理生理学尚未完全理解,但生物力学因素被怀疑起作用.
- 以前的研究主要集中在解剖学描述上,生物力学分析有限.
研究的目的:
- 从LVAS患者的CT图像中建立内耳的3D数值模型.
- 使用流体-固体合模型分析LVAS的生物力学特征和病理生理学.
- 为了研究前庭管道 (VA) 尺寸和内耳压力动态之间的关系.
主要方法:
- 从五名儿科LVAS患者获得了骨的计算机断层扫描 (CT) 图像.
- 使用模仿和Geomagic软件构建了包括前庭水道 (VA) 在内的3D内耳模型.
- 液体-固体合分析使用ANSYS软件与圆窗膜模型进行.
主要成果:
- 包含VA的内耳的3D数值模型从临床CT数据成功建立.
- 增加的压力负荷导致圆形窗户膜变形和应力增加.
- 较大的VA尺寸与在同等负载下增加圆窗膜的变形和应力相关.
结论:
- 临床CT图像可用于创建用于生物机械分析的全面3D内耳模型.
- 大脑脊髓液压力波动会影响内耳压力.
- 前庭水道 (VA) 作为压力调节器;较大的VA表现出压力限制效应的减弱.
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