Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Antibiofilm efficacy of zwitterionic 2-methacryloloxyethyl phosphorylcholine (MPC) polymer coatings against Vibrio fischeri.

Water research·2026
Same author

Sphingosine-1-phosphate cross-talks to Notch via a S1PR1-Dll4-MPDZ complex to regulate endothelial barrier function.

bioRxiv : the preprint server for biology·2026
Same author

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A 3D In Vitro Model of the Human Hepatobiliary Junction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Synthetic control of implanted engineered liver tissue growth.

Science advances·2026
Same author

A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks.

Lab on a chip·2026

相关实验视频

Updated: Jul 28, 2025

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.4K

工程心脏组织的高吞吐量查系统.

Marshall S Ma1,2, Subramanian Sundaram3, Lihua Lou4

  • 1Mechanical Engineering, Boston University, Boston, MA, United States.

Frontiers in bioengineering and biotechnology
|May 30, 2023
PubMed
概括
此摘要是机器生成的。

一个新的马赛克成像系统通过在3D工程心脏组织 (3D ECT) 中实现高通量,实时监测收缩力来增强药物心脏毒性查. 这一创新大大减少了临床前药物开发的测试时间和成本.

关键词:
在PDMS中使用PDMS.心脏毒性查对心脏有毒性的检查.工程心脏组织的工程心脏组织.高吞吐量成像技术 (HTI)微型制造业的微型制造业

更多相关视频

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

1.9K

相关实验视频

Last Updated: Jul 28, 2025

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.4K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

1.9K

科学领域:

  • 生物医学工程 生物医学工程
  • 心血管研究研究心血管研究
  • 药物发现 药物发现 药物发现

背景情况:

  • 三维工程心脏组织 (3D ECT) 对于评估药物心脏毒性的体外模型至关重要.
  • 目前用于测量3D ECT收缩力的方法具有低通量,这限制了它们在药物开发中的使用.
  • 现有的成像技术面临分辨率,视野和速度之间的权衡,限制了同时分析的样本数量.

研究的目的:

  • 开发和验证一个创新的马赛克成像系统,用于3D ECT的高通量收缩力传感.
  • 在速度,分辨率和视野方面克服传统成像的局限性.
  • 为了实现并行,实时监控收缩力在一个96井板格式.

主要方法:

  • 一个新的马赛克成像系统的设计和建造.
  • 在一个96井板上播种3D ECT.
  • 通过实时,并行收缩力监测三周系统的验证.
  • 使用异二醇进行试点药物测试.

主要成果:

  • 马赛克成像系统成功地同时监测了3D ECT的收缩力,长达三周.
  • 该系统展示了执行试点药物测试的能力,展示了其实际应用.
  • 收缩力传感的吞吐量增加到每次测量的96个样本.

结论:

  • 开发的马赛克成像工具显著提高了使用3D ECT进行临床前心脏毒性测试的吞吐量.
  • 这种方法减少了与药物安全测试相关的成本,时间和劳动力.
  • 马赛克策略提供了一种可通用的方法,用于扩大基于图像的选在多井板格式.