横向基因转移是否有利于合作?
Thomas W Scott1, Stuart A West1, Anna E Dewar1
1Department of Biology, University of Oxford, Oxford, United Kingdom.
Evolution letters
|May 30, 2023
概括
在等离子体上水平基因转移可以促进细菌的合作,但只有当等离子体是罕见的. 当常见时,等离子体减少了合作,导致了整体的低等离子体介导合作.
科学领域:
- 进化生物学是进化的生物学.
- 微生物遗传学微生物遗传学
- 理论生态学的理论生态学.
背景情况:
- 通过等离子体进行横向基因转移 (HGT) 是细菌进化的关键机制.
- 假设等离子体可以增加遗传相关性,从而促进合作.
研究的目的:
- 从理论上研究HGT对合作演变的影响.
- 为了确定等离子体频率和细菌合作之间的关系.
主要方法:
- 用等离子体对细菌种群的数学建模.
- 在不同的等离子体频率下分析遗传关系和合作动态.
主要成果:
- 只有当等离子体稀有时,HGT才能显著增加遗传相关性.
- 当等离子体很常见时,HGT的机会减少,限制了相关性和合作.
- 等离子体在进化过程中要么是稀有且有合作性,要么是常见且无合作性.
结论:
- 等离子体并不总是有利于高水平的合作.
- 质粒的频率和它们的合作性是反向相关的.
- 总体而言,等离子体介导的合作通常是可以忽略的或低.
相关概念视频
Horizontal Gene Transfer
45
Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
45
Types of Genetic Transfer Between Organisms
28.8K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
28.8K
Conjugation
37
Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
37
Transduction
49
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
49
Genome Size and the Evolution of New Genes
8.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.0K
Mechanism of Conjugation
47
Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
47


