六个月的定期禁食不会影响2型糖尿病患者体感神经功能
Zoltan Kender1,2, Ekaterina von Rauchhaupt1,2, Daniel Schwarz3
1Clinic for Endocrinology, Diabetology, Metabolic Diseases and Clinical Chemistry (Internal Medicine 1), Heidelberg University Hospital, Heidelberg, Germany.
Frontiers in endocrinology
|May 30, 2023
概括
定期禁食在2型糖尿病患者中安全地保留了神经功能,在六个月内对体感神经功能没有有害影响.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 预防糖尿病感觉运动性多神经病变 (DSPN) 是有限的,血糖控制可能会恶化神经功能.
- 快速的血糖变化可以矛盾地加剧DSPN.
研究的目的:
- 研究定期禁食对2型糖尿病 (T2D) 患者体感神经功能的影响.
- 评估与地中海饮食 (M-饮食) 相比,禁食模仿饮食 (FMD) 是否会影响神经功能.
主要方法:
- 31名T2D患者 (HbA1c 7.8%) 在6个月口病 (n=14) 或M饮食 (n=17) 之前和之后进行了评估.
- 评估包括神经病症评分 (NDS,NSS),神经传导速度 (NCV),定量感官测试 (QST) 和磁共振神经图 (MRN).
主要成果:
- 两组之间没有观察到临床神经病症得分或感官神经传导的显著变化.
- 关节炎组显示部神经运动导电保持 (CMAP增加了18%),与M饮食组相比,它减少了.
- M饮食组的热痛值有所下降,而口疫组没有.
结论:
- 六个月的定期禁食 (FMD) 对T2D患者来说是安全的.
- 定期禁食表明对神经功能有保护作用,没有观察到任何不良结果.
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