带有贝利费龙的PEGylated脂质体:制备,表征及其对达尔顿炎淋巴瘤发展的缓解作用
Prathapan Abeesh1, Chandrasekharan Guruvayoorappan1
1Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Medical College Campus, Thiruvananthapuram, Kerala 695 011 India.
3 Biotech
|May 30, 2023
概括
这项研究开发了贝利费龙封装纳米脂质体 (nLUB),以提高抗瘤疗效. 在淋巴瘤模型中,纳米脂质体增强了细胞吸收,减少了瘤生长,并改善了生存率.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 乌贝利费龙 (UB) 具有抗瘤特性,但具有较低的溶解性和生物可用性.
- 需要有效的传递系统来增强UB的治疗潜力.
研究的目的:
- 开发和表征贝利费龙封装纳米脂质体 (nLUB).
- 为了评估nLUB对Dalton's ascites淋巴瘤的增强抗瘤疗效.
主要方法:
- 用薄膜水化方法制备封装UB的纳米脂质体.
- 描述包括粒子大小,表面电荷和封装效率.
- 在体外和体外研究中,使用淋巴瘤细胞和瘤模型进行了研究.
主要成果:
- nLUB的粒子大小为116nm,表面电荷为负,封装效率为78%.
- 实验室研究显示,nLUB.增强了细胞吸收和细胞亡诱导.
- 在体内,nLUB稳定了体重,减少了瘤生长,改善了生化/血液学参数,并增加了生存率.
结论:
- 纳米封装显著提高了贝利费龙的治疗疗效.
- nLUB证明了在癌症治疗中临床应用的潜力.
相关概念视频
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include: