自组合在缓解胃肠病变晚期内切除后延迟出血的有效性:一个元分析
Harishankar Gopakumar1, Ishaan Vohra1, Neil R Sharma2
1Department of Gastroenterology and Hepatology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States.
Endoscopy international open
|May 30, 2023
概括
一种新型的自组合 (SAP) 溶液有效地减少了胃肠病变的先进内镜切除后的延迟出血. 这次元分析发现SAP是安全的,没有报告的不良事件,为患者护理提供了一个有前途的选择.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 生物材料是一种生物材料.
背景情况:
- 对于胃肠病变的先进内镜切除技术具有延迟出血 (DB) 的风险.
- 一种全新合成自组合 (SAP) 已成为减轻这种风险的潜在解决方案.
- 评估SAP在预防DB的有效性和安全性对于改善患者的治疗结果至关重要.
研究的目的:
- 进行一项元分析,评估SAP在胃肠道光线病变的先进内镜切除后减少DB的有效性.
- 分析可用研究的汇总数据,以量化DB率的降低.
- 评估SAP的安全概况,特别是寻找任何报告的不良事件 (AE).
主要方法:
- 从2010年1月到2022年10月,在主要的电子数据库 (PubMed,Embase,Cochrane图书馆) 中进行了系统的文献搜索.
- 包括涉及在接受胃肠病变先进内镜切除的患者中使用SAP溶液的研究.
- 使用固定和随机效应模型计算了DB和AE的聚合比例.
主要成果:
- 分析包括了6项研究,涉及307名患者. 汇总的DB比率为5.73%.
- 患者的平均年龄为69.40岁,平均切除病变大小为36.20毫米.
- 内镜下粘膜解剖 (72.69%) 和内镜粘膜切除 (26.42%) 是主要的程序. 36%的患者正在服用抗血栓药物.
- 没有任何不良事件归因于SAP的使用,AE的汇总率为0.00%.
结论:
- 在高风险胃肠病变的先进内镜切除后,SAP溶液在减少手术后延迟出血方面显示出显著的希望.
- 在这种情况下,SAP的使用与良好的安全性相关,没有报告的不良事件.
- SAP代表了提高先进内镜切除的安全性和有效性的潜在有价值的工具.
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