在肥胖患者的结肠镜检查期间进行有意识镇静的德克斯梅托米丁-氧化组合:一个随机对照试验
Xinran Wang1, Manman Zhang2, Han Sun2
1Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Heliyon
|May 30, 2023
概括
在接受结肠镜检查的肥胖患者中,德克斯梅德托米丁加氧提供了更安全的有意识镇静,减少了低氧化和改善了与普罗波相比的恢复时间. 这种组合增强了程序的方便性和患者的结果.
科学领域:
- 麻醉学 麻醉学
- 胃肠病学 胃肠病学
- 临界护理医学 临界护理医学
背景情况:
- 肥胖是结肠镜检查期间与镇静相关的呼吸道并发症的重要危险因素.
- 普罗波是一种常见的镇静剂,在肥胖患者中与严重的呼吸抑制有关.
- 需要采用替代镇静策略,以提高这一群体的安全性和有效性.
研究的目的:
- 评估德克斯梅托米丁加氧在肥胖患者结肠镜检查期间对有意识镇静剂的有效性和安全性.
- 为了在镇静质量和患者结局方面比较这种组合与普罗波加氧.
- 评估对程序困难和恢复指标的影响.
主要方法:
- 一项随机对照试验,涉及120名接受结肠镜检查的肥胖患者.
- 患者被分配给接受德克斯梅托米丁加氧 (Dex + oxy) 或普罗波加氧 (Pro + oxy) 进行镇静.
- 监测的关键参数包括呼吸状况,血液动力学,注射疼痛和恢复时间.
主要成果:
- 德克塞梅托米丁加氧组的低氧血症发病率显著降低 (4.9%对比20.3%).
- 这一组还显示了更短的方向和行走恢复时间,以及更好的内镜医生满意度.
- 血动力学上的差异包括在普罗波组的血压降低和心率升高.
结论:
- 在结肠镜检查期间,德克斯梅德托米丁加氧可为肥胖患者提供有效和安全的有意识镇静.
- 这种方案减少了呼吸系统不良事件,并促进了更容易的重新定位,改善了程序结果.
- 在这个患者群体中,它代表了基于普罗波的镇静剂的可行替代品.
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