消防员癌症风险和死亡率:一个元分析性综述
David J Lee1,2, Soyeon Ahn3, Laura A McClure1,2
1Department Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Frontiers in oncology
|May 30, 2023
概括
消防员的癌症风险总体较低,但对于黑色素瘤和前列腺癌等特定癌症更高. 为了有针对性的癌症监测和了解暴露风险,需要进一步的研究.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 消防员是高风险的职业,有证据表明与癌症发病率的增加有关.
- 越来越多的研究需要对消防员癌症风险的研究结果进行综合.
研究的目的:
- 进行元分析,综合现有关于消防员癌症风险和死亡率的研究.
- 为了确定特定的癌症类型,在这个人群中增加发病率或死亡率.
主要方法:
- 按照PRISMA指南进行了系统的文献搜索.
- 计算了聚合的标准化发病风险 (SIRE) 和标准化死亡率估计 (SMRE).
- 对38项研究 (1978-2022) 进行了出版偏见和调节者分析.
主要成果:
- 与一般人口相比,消防员的总体癌症发病率和死亡率较低 (SIRE=0.93,SMRE=0.93).
- 皮肤黑色素瘤 (SIRE=1.14),其他皮肤癌 (SIRE=1.24) 和前列腺癌 (SIRE=1.09) 的风险增加.
- 在直肠,丸和非霍奇金淋巴瘤中发现死亡率更高.
结论:
- 消防员面临特定癌症的风险增加,包括黑色素瘤和前列腺癌,这表明需要量身定制的癌症监测.
- 需要进一步进行纵向研究,以调查暴露特异性风险和研究不足的癌症亚型.
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