在2型糖尿病中,高尿血-腰部表型和阻塞性睡眠呼吸暂停之间的关系
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
在2型糖尿病 (T2DM) 中,一种新的高尿血症-腰部 (HUAW) 现型与阻塞性睡眠呼吸暂停 (OSA) 有关. 患有T2DM和HUAW表型的患者患有中度至重度OSA的风险更高.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 2型糖尿病 (T2DM) 是一种复杂的代谢障碍.
- 阻塞性睡眠呼吸暂停 (OSA) 是T2DM中常见的并发症.
- 超尿血症-腰部 (HUAW) 现型,其特征是血清尿酸升高和腰围增加,此前尚未与T2DM中的OSA相关研究.
研究的目的:
- 提出高尿血症-腰部 (HUAW) 现型.
- 研究2型糖尿病 (T2DM) 患者中HUAW表型和阻塞性睡眠呼吸暂停 (OSA) 之间的关联.
主要方法:
- 一组255名T2DM患者 (165名男性,90名女性) 接受了睡眠测试.
- 测量了血清尿酸 (UA) 水平和腰围 (WC).
- HUAW表型被定义为UA≥420μmol/L和WC≥90厘米 (男性) 或≥85厘米 (女性).
- 根据UA和WC水平,参与者被分为四组.
主要成果:
- 17.6%的参与者表现出HUAW表型.
- 整体OSA患病率为80.0%,其中47.0%患有中度至重度OSA.
- 在所有表型组中,OSA的患病率逐渐增加 (43.4%至97.8%).
- 中度至重度OSA的患病率也随着HUAW表型显著增加 (7.5%至72.7%).
- 经过调整后的分析证实了HUAW表型与OSA之间存在显著的关联,特别是中度至重度的OSA.
结论:
- HUAW表型与T2DM患者的OSA患病率增加有关.
- 患有HUAW表型的T2DM患者患有中度至重度OSA的风险要高得多.
- 对于被确定为HUAW表型的T2DM个体,建议进行常规睡眠研究.
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